Depression and Suicidality of Intranasal Ketamine: Current Evidence
نویسندگان
چکیده
منابع مشابه
Ketamine for treatment-resistant unipolar depression: current evidence.
Currently available drugs for unipolar major depressive disorder (MDD), which target monoaminergic systems, have a delayed onset of action and significant limitations in efficacy. Antidepressants with primary pharmacological targets outside the monoamine system may offer the potential for more rapid activity with improved therapeutic benefit. The glutamate system has been scrutinized as a targe...
متن کاملOral ketamine augmentation for chronic suicidality in treatment-resistant depression.
In a recent article in this journal, the effectiveness of intravenous ketamine in treatment-resistant depression was highlighted (Katalinic et al., 2013). The following case reports describe the use of oral ketamine as augmentation treatment in patients presenting with chronic suicide ideation and at least two significant past suicide attempts. Mr B was a 44-year-old male with a history of bipo...
متن کاملIntranasal drug delivery in neuropsychiatry: focus on intranasal ketamine for refractory depression.
Intranasal drug delivery (INDD) systems offer a route to the brain that bypasses problems related to gastrointestinal absorption, first-pass metabolism, and the blood-brain barrier; onset of therapeutic action is rapid, and the inconvenience and discomfort of parenteral administration are avoided. INDD has found several applications in neuropsychiatry, such as to treat migraine, acute and chron...
متن کاملWarning: Depression and Suicidality
WARNING: DEPRESSION AND SUICIDALITY See full prescribing information for complete boxed warning. Increases the risk of depression and suicidal thoughts and behavior (suicidality) in patients with Huntington’s disease. Balance risks of depression and suicidality with the clinical need for control of choreiform movements when considering the use of XENAZINE. Monitor patients for the emergence or ...
متن کاملEffects of intravenous ketamine on explicit and implicit measures of suicidality in treatment-resistant depression.
BACKGROUND Intravenous ketamine has shown rapid antidepressant effects in early trials, making it a potentially attractive candidate for depressed patients at imminent risk of suicide. The Implicit Association Test (IAT), a performance-based measure of association between concepts, may have utility in suicide assessment. METHODS Twenty-six patients with treatment-resistant depression were ass...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Psychology and Mental Health Care
سال: 2018
ISSN: 2637-8892
DOI: 10.31579/2637-8892/036